Wnt ligands from the embryonic surface ectoderm regulate bimetallic strip optic cup morphogenesis in the mouse
Ontology highlight
ABSTRACT: Wnt signaling in early eye development, specifically the lens placode shows expression of 12 out of 19 Wnt ligands. We these Wnt activities were suppressed using conditional deletion of Wntless, dramatic phenotypic changes in morphogensis occurred. Microarray analysis of the genes that were changed in response to deletion of Wnt ligands in the developing eye region show direct or indirect responses from the surface ectoderm to the developing RPE and optic cup curvature, creating an overal shape change phenotype in the bilayerd epithelium of the optic cup.
ORGANISM(S): Mus musculus
PROVIDER: GSE65154 | GEO | 2015/01/22
SECONDARY ACCESSION(S): PRJNA273288
REPOSITORIES: GEO
ACCESS DATA