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MRNA expression in white adipose tissue of adult F2 female offspring from F0-fathers fed a chow or high-fat diet

ABSTRACT: The purpose of this study was to investigate whether paternal high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa to alter metabolism in the F1 and F2 generation offspring White adipose tissue mRNA expression profiling of F2-female offspring from F0-founders fed either a chow or a chronic HFD challenged. Adult females were challenged or not a high-fat diet for 12 weeks. White adipose tissue was dissected at an endpoint experiment. Rats were subjected to 4 hours fasting prior to anesthesia with pentobarbital and tissue collection.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE65182 | GEO | 2017/01/01

SECONDARY ACCESSION(S): PRJNA273353

REPOSITORIES: GEO

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