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Comprehensive genomic analysis of relapse neuroblastoma [arrayCGH]

ABSTRACT: Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. This data set contains the aCGH data.

ORGANISM(S): Homo sapiens

PROVIDER: GSE65304 | GEO | 2015/06/19

SECONDARY ACCESSION(S): PRJNA273713

REPOSITORIES: GEO

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Comprehensive genomic analysis of relapse neuroblastoma [arrayCGH]

Project description:Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. This data set contains the aCGH data. Array from tumours at relapse were compared to pretreatment tumours and corresponding normal samples.

2015-06-19 | E-GEOD-65304 | biostudies-arrayexpress

Comprehensive genomic analysis of relapse neuroblastoma [methylation]

Project description:Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. This data set contains genome-wide methylation data.

2015-06-19 | GSE65306 | GEO

Comprehensive genomic analysis of relapse neuroblastoma [methylation]

Project description:Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. This data set contains genome-wide methylation data. Array from tumours at relapse were compared to pretreatment tumours and corresponding normal samples.

2015-06-19 | E-GEOD-65306 | biostudies-arrayexpress

Comprehensive genomic analysis of relapse neuroblastoma [gene expression]

Project description:Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. Here we describe the expression data.

2015-06-19 | GSE65303 | GEO

Comprehensive genomic analysis of relapse neuroblastoma [gene expression]

Project description:Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. Here we describe the expression data. Array from tumours at relapse were compared to pretreatment tumours and corresponding normal samples.

2015-06-19 | E-GEOD-65303 | biostudies-arrayexpress

Pituitary Gigantism ArrayCGH

Project description:Pituitary Gigantism ArrayCGH

| PRJNA940053 | ENA

Oligonucleotide-based arrayCGH

Project description:Oligonucleotide-based arrayCGH

| PRJNA92921 | ENA

Comprehensive genomic analysis of relapse neuroblastoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-06-19 | GSE65307 | GEO

Homo sapiens

Project description:Comprehensive genomic analysis of relapse neuroblastoma [arrayCGH]

| PRJNA273713 | ENA

Integrated genomic analysis of chromosomal alterations and mutations in B-cell acute lymphoblastic leukemia reveals distinct genetic profiles at relapse

Project description:Background: The clonal basis of relapse in acute lymphoblastic leukemia (ALL) is complex and not fully understood. Methods: Next-generation sequencing (NGS), array comparative genomic hybridization (aCGH), and multiplex-ligation-dependent probe amplification (MLPA) were carried out in matched diagnosis-relapse samples from 13 B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients to identify patterns of genetic evolution that could account for the phenotypic changes associated with disease relapse. Findings: The integrative genomic analysis of aCGH, MLPA and NGS revealed that 100% of BCP-ALL patients showed at least one genetic alteration at diagnosis and relapse. In addition, there was a significant increase in the frequency of chromosomal lesions at the time of relapse (median, 6 alterations per sample) relative to that at diagnosis (median, 47 alterations) (p = 0.019). The combination of MLPA and aCGH techniques showed that IKZF1 was the most frequently deleted gene. Notably, TP53 was the most frequently mutated gene at relapse (31%). Two TP53 mutations were detected only at relapse, whereas the three others showed an increase of their mutational burden at relapse. Interpretation: Clonal evolution patterns were heterogeneous, involving acquisition, loss and maintenance of lesions at relapse. Therefore, this study confirmed that BCP-ALL is a genetically dynamic disease with distinct genetic profiles at diagnosis and relapse. The combination of the NGS, aCGH, and MLPA approaches enables better molecular characterization of the genetic profile in ALL patients during the evolution from diagnosis to relapse.

2020-08-12 | GSE128031 | GEO

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