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Gene expression profiling in response to radiation treatment in human breast cancer

ABSTRACT: Treatment-related morbidities have been linked to the large post-operative treatment volumes required for external beam partial breast irradiation (PBI). Alternative PBI techniques require equipment that is not readily available. To address these issues, we designed a phase I trial utilizing widely available technology to 1) evaluate the safety of a single radiation treatment delivered preoperatively to the small-volume, intact breast tumor and 2) identify imaging and genomic markers of radiation response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE65505 | GEO | 2015/10/31

SECONDARY ACCESSION(S): PRJNA274283

REPOSITORIES: GEO

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Gene expression profiling in response to radiation treatment in human breast cancer

Project description:Treatment-related morbidities have been linked to the large post-operative treatment volumes required for external beam partial breast irradiation (PBI). Alternative PBI techniques require equipment that is not readily available. To address these issues, we designed a phase I trial utilizing widely available technology to 1) evaluate the safety of a single radiation treatment delivered preoperatively to the small-volume, intact breast tumor and 2) identify imaging and genomic markers of radiation response. Women 55 or older with clinically node negative, ER+ and/or PR+, HER2-, T1 invasive carcinomas or low-intermediate grade in situ disease â¤2cm were enrolled (n=32). Intensity-modulated radiotherapy was used to deliver 15 Gy (n=8, patients 01-08), 18 Gy (n=8, patients 09-16), or 21Gy (n=16, patients 17-32) to the tumor with a 1.5cm margin. Lumpectomy was performed within 10 days. Paired pre- and post-radiation MRI images and patient tumor samples were analyzed.

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Project description:Intervention1: Radiation in prone position using Belly Board device: Comercially available device used to treat patients in prone position who are undergoing external beam pelvic radiation.Patients lie prone on the device during treatment.External beam radiation of 40-45 Gy in 1.8-2 Gy per fraction,one fraction daily,5 days a week, for 4-5 week duration. Control Intervention1: Radiation in supine position: External beam radiation in supine position.External beam radiation of 40-45 Gy in 1.8-2 Gy per fraction,one fraction daily,5 days a week,for 4-5 week duration.

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Project description:Breast cancer (BC) recovery has considerably increased thanks to the advances achieved from research in this field. However, despite the important results obtained, BC remains a complex multifactorial disease with distinct subtypes associated with different outcomes.So, many efforts from radiobiological research are needed to help clinicians in understanding molecular features of a specific tumor subtype, in order to better define the most successful treatment plan, including the choice of the best Radiation Teraphy (RT) modality and schedule in clinical practice. The aim of the present study was to analyze the GEPs in primary breast cancer cells following irradiation with doses of 9 Gy and 23 Gy electron beam delivered by IOERT treatment, in order to define gene signatures of response to high doses of IR.

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