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LncRNAs expression signatures of cumulus cells isolated from PCOS patients revealed by microarray

ABSTRACT: Our study is the first one to determine genome-wide lncRNAs expression patterns in cumulus cells of PCOS patients by microarray. The results displayed that clusters of lncRNAs (n=623) were aberrantly expressed in PCOS patients compared with non-PCOS patients. Many differentially expressed lncRNAs were transcribed from regions on chromosome 2 and classified into enhancer-like lncRNA subgroup. XLOC_011402 (PWRN2) was found for the first time that it was not only expressed in testis but also in cumulus cells. All the results revealed that lncRNAs differentially expressed in cumulus cells may exert a partial or key role in hormone abnormalities of PCOS patients and maybe impact on oocyte development. Taken together, this study may provide potential targets for further treatment of PCOS and novel insights into oocyte development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE65746 | GEO | 2016/02/01

SECONDARY ACCESSION(S): PRJNA274902

REPOSITORIES: GEO

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