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Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE65923 | GEO | 2015/09/24

SECONDARY ACCESSION(S): PRJNA275413

REPOSITORIES: GEO

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Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-09-24 | E-GEOD-65923 | biostudies-arrayexpress

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [RNA-seq]

Project description:Neonates are intrinsically defective at creating memory CD8+ T cells in response to infection with intracellular pathogens. Here we investigated differential of small RNAs, transcription factors, and chemokine receptors regulation in neonates as compared to adults before and during infection. We found that prior to infection, naïve cells have a different expression profile for many microRNAs, and gene targets of these microRNAs show widespread expression differences. These targets and other changes in gene expression in naïve cells result in neonatal cells that get activated more easily, express chemokine receptors that home to sites of infection, and are less protected from apoptosis during contraction. As a result, changes in neonatal naïve cells drive effector cell terminal differentiation at the expense of creating long-lived memory cells. total RNAs were sequenced from adult and neonatal CD8+ T cells before and during infection

2015-09-24 | E-GEOD-65922 | biostudies-arrayexpress

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [small-RNA seq]

Project description:Neonates are intrinsically defective at creating memory CD8+ T cells in response to infection with intracellular pathogens. Here we investigated differential of small RNAs, transcription factors, and chemokine receptors regulation in neonates as compared to adults before and during infection. We found that prior to infection, naïve cells have a different expression profile for many microRNAs, and gene targets of these microRNAs show widespread expression differences. These targets and other changes in gene expression in naïve cells result in neonatal cells that get activated more easily, express chemokine receptors that home to sites of infection, and are less protected from apoptosis during contraction. As a result, changes in neonatal naïve cells drive effector cell terminal differentiation at the expense of creating long-lived memory cells. Small RNAs were sequenced from adult and neonatal CD8+ T cells before and during infection

2015-09-24 | E-GEOD-65920 | biostudies-arrayexpress

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [human miRNA-seq]

Project description:Neonates are intrinsically defective at creating memory CD8+ T cells in response to infection with intracellular pathogens. Here we investigated differential of small RNAs, transcription factors, and chemokine receptors regulation in neonates as compared to adults before and during infection. We found that prior to infection, naïve cells have a different expression profile for many microRNAs, and gene targets of these microRNAs show widespread expression differences. These targets and other changes in gene expression in naïve cells result in neonatal cells that get activated more easily, express chemokine receptors that home to sites of infection, and are less protected from apoptosis during contraction. As a result, changes in neonatal naïve cells drive effector cell terminal differentiation at the expense of creating long-lived memory cells. Small RNAs were sequenced from adult and neonatal CD8+ T cells before infection.

2015-09-24 | E-GEOD-66650 | biostudies-arrayexpress

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [3'UTR-seq]

Project description:Neonates are intrinsically defective at creating memory CD8+ T cells in response to infection with intracellular pathogens. Here we investigated differential of small RNAs, transcription factors, and chemokine receptors regulation in neonates as compared to adults before and during infection. We found that prior to infection, naïve cells have a different expression profile for many microRNAs, and gene targets of these microRNAs show widespread expression differences. These targets and other changes in gene expression in naïve cells result in neonatal cells that get activated more easily, express chemokine receptors that home to sites of infection, and are less protected from apoptosis during contraction. As a result, changes in neonatal naïve cells drive effector cell terminal differentiation at the expense of creating long-lived memory cells. PolyA RNA was selected and sequenced from adult and neonatal CD8+ T cells before and during infection

2015-09-24 | E-GEOD-65921 | biostudies-arrayexpress

Gene expression profiles of CD8+ partial memory T cells (Tpm) compared to naive, effector and memory CD8+ T cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-04-30 | E-GEOD-27139 | biostudies-arrayexpress

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [RNA-seq]

2015-09-24 | GSE65922 | GEO

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [miRNA-Seq]

2015-09-26 | GSE73459 | GEO

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [3'UTR-seq]

2015-09-24 | GSE65921 | GEO

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [small-RNA seq]

2015-09-24 | GSE65920 | GEO