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Genome-wide anaylsis of histone acetylation during mouse ESC differentiation [ChIP-seq]

ABSTRACT: Using acetylated histone H3 ChIP-seq, we reveal that the histone H3 acetylation level is gradually increased on the neural gene loci while decreased on the neural-inhibitory gene loci during mouse ESC neural differentiation. By overlapping with the targets of HDAC1 ChIP-seq, we identify Nodal as a target gene repressed by histone deacetylation. Thus, our study reveals an intrinsic mechanism that epigenetic histone deacetylation ensures neural fate commitment by restricting Nodal signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE66025 | GEO | 2015/02/19

SECONDARY ACCESSION(S): PRJNA275705

REPOSITORIES: GEO

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Genome-wide anaylsis of histone acetylation during mouse ESC differentiation [ChIP-seq]

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