Genome-wide anaylsis of histone acetylation during mouse ESC differentiation [ChIP-seq]
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ABSTRACT: Using acetylated histone H3 ChIP-seq, we reveal that the histone H3 acetylation level is gradually increased on the neural gene loci while decreased on the neural-inhibitory gene loci during mouse ESC neural differentiation. By overlapping with the targets of HDAC1 ChIP-seq, we identify Nodal as a target gene repressed by histone deacetylation. Thus, our study reveals an intrinsic mechanism that epigenetic histone deacetylation ensures neural fate commitment by restricting Nodal signaling.
ORGANISM(S): Mus musculus
PROVIDER: GSE66025 | GEO | 2015/02/19
SECONDARY ACCESSION(S): PRJNA275705
REPOSITORIES: GEO
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