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Occupancy of Mll1 in ESCs and transcriptome of ESCs, EpiSCs and reverted ES by MM401 (Mll1 inhibitor)

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE66112 | GEO | 2016/02/19

SECONDARY ACCESSION(S): PRJNA275896

REPOSITORIES: GEO

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Occupancy of Mll1 in ESCs and transcriptome of ESCs, EpiSCs and reverted ES by MM401 (Mll1 inhibitor)

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-02-19 | E-GEOD-66112 | biostudies-arrayexpress

Transcriptome of ESCs, EpiSCs and reverted ES by MM401 (Mll1 inhibitor) #2

Project description:This study describes the transcriptome profiling of: 1) mouse ES cells in LIF/KSR medium; 2)EpiSCs in bFGF/serum-free (KSR) medium; 3) EpiSCs treated with MM401/LIF KSR at D3 and D6 (P2); 4) rES reverted form EpiSC by MM401/LIF KSR treatment at P6, P30 with or without MM401 .

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Transcriptome of ESCs, EpiSCs and reverted ES by MM401 (Mll1 inhibitor)

Project description:This study describes the transcriptome profiling of: 1) mouse ES cells and EpiSCs in LIF/serum-free (KSR) medium; 2) E14Tg2a (E14) ES cells in LIF/Serum with or without MM401 treatment; 3) rES reverted form EpiSC by MM401/LIF KSR treatment at P6, P30. RNA-Seq profiling on mouse pluripotent cells. Biological duplicates of each sample are labled as rep1/2.

2016-02-19 | E-GEOD-66110 | biostudies-arrayexpress

Occupancy of Mll1 in ESCs and transcriptome of ESCs, EpiSCs and reverted ES by MM401 (Mll1 inhibitor)

Project description:Occupancy of Mll1 in ESCs and transcriptome of ESCs, EpiSCs and reverted ES by MM401 (Mll1 inhibitor)

| PRJNA275896 | ENA

Transcriptome and epigenome of ESCs upon MLL1 inhibition/deletion

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-12-02 | GSE107408 | GEO

Project description:Predominant transcriptional subnetworks called Core, Myc, and PRC modules have been shown to participate in preservation of the pluripotency and self-renewality of embryonic stem cells (ESCs). Epiblast stem cells (EpiSCs) are another cell type that possesses pluripotency and self-renewality. However, the roles of these modules in EpiSCs have not been systematically examined to date. Here, we compared the average expression levels of Core, Myc, and PRC module genes between ESCs and EpiSCs. EpiSCs showed substantially higher and lower expression levels of PRC and Core module genes, respectively, compared with those in ESCs, while Myc module members showed almost equivalent levels of average gene expression. Subsequent analyses revealed that the similarity in gene expression levels of the Myc module between these two cell types was not just overall, but striking similarities were evident even when comparing the expression of individual genes. We also observed equivalent levels of similarity in the expression of individual Myc module genes between induced pluripotent stem cells (iPSCs) and partial iPSCs that are an unwanted byproduct generated during iPSC induction. Moreover, our data demonstrate that partial iPSCs depend on a high level of c-Myc expression for their self-renewal properties.

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Transcriptome of ESCs upon MLL1 inhibition/deletion

Project description:This study describes the transcriptome profiling of: 1) Mll1fl/fl mESCs in LIF/Serum medium as control; 2) Mll1fl/fl mESCs with 4-OHT (Mll1-/-), MM-401 (Mll1i) in LIF/serum medium ; 2) Mll1fl/fl mESCs with 2i in LIF/serum-free (KSR) medium.

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Transcriptome of ESCs upon VD3 treatment (+/-) MLL1 inhibition

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Transcriptome of ESCs upon MLL1 inhibition/deletion

Project description:Transcriptome of ESCs upon MLL1 inhibition/deletion

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Single cell transcriptome of ESCs upon MLL1 inhibition/deletion

Project description:This study describes the single-cell transcriptome profiling of: 1) Mll1fl/fl mESCs as control; 2) Mll1fl/fl mESCs with 4-OHT (Mll1-/-) or with MM-401 (Mll1i) in LIF/15KSR/5% serum KO DMEM medium on Matrigel.

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