Transcriptomics

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Gene expression in human lymphoblastoid cell-line GM12878 in response to sulforaphane treatment


ABSTRACT: To determine if induced NRF2 binding is associated with gene expression in genome-wide. We examined mRNA levels with theAffymetrix Human Exon 1.0 ST platform in human lymphoblastoid GM12878 cells treated with sulforaphane to activate NRF2. Nrf2, a basic leucine zipper transcription factor encoded by the gene NFE2L2, is a master regulator of the transcriptional response to oxidative stress. Nrf2 is structurally and functionally conserved from insects to humans, and it heterodimerizes with the small Maf transcription factors to bind a consensus DNA sequence (the antioxidant response element, or ARE) and regulate gene expression. In this study, we use chromatin immunoprecipitation (ChIP-seq) and gene expression data to identify direct Nrf2 target genes in human and Drosophila.

ORGANISM(S): Homo sapiens

PROVIDER: GSE66164 | GEO | 2017/02/18

SECONDARY ACCESSION(S): PRJNA275996

REPOSITORIES: GEO

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