Insights into molecular characteristics of anaplastic large cell lymphoma by genome-wide DNA methylation profiling
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ABSTRACT: Aberrant DNA methylation patterns of malignant cells allow for the study of the tumor phenotype and behavior, and can be used for tumor classification. Here, we describe the genome-wide DNA methylation signatures of NPM-ALK positive and negative anaplastic large cell lymphoma (ALCL). Differences in DNA methylation of tumor cells compared to normal T cells concern pathways that are implicated in T cell development and function and reveal a close relationship to distinct developmental stages of thymocytes. We find DNA hypomethylation in regulatory regions that are enriched for conserved transcription factor binding motifs, such as AP1. Our results suggest a direct relationship of oncogenic signaling with epigenetic modifications via transcription factor induction and occupancy.
ORGANISM(S): Homo sapiens
PROVIDER: GSE66881 | GEO | 2015/04/01
SECONDARY ACCESSION(S): PRJNA278155
REPOSITORIES: GEO
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