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Cardiac differentiation time-courses of human ES cells investigating the requirement for intermediate WNT inhibition

ABSTRACT: Efficient directed cardiac induction of human embryonic stem cells requires an intermediate inhibition of WNT signaling, shortly after the initial induction of mesoderm. To reveal the significance of the WNT inhibition step during differentiation, two differential time-course analyses were performed - both comparing WNT-inhibited and non-WNT-inhibited samples: In the first time-course, the WNT inhibitor IWP-2 was either added or omitted on days 2 and 3, and in the second time-course, IWP-2 was either added or omitted on days 1 and 2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE67152 | GEO | 2015/11/13

SECONDARY ACCESSION(S): PRJNA279189

REPOSITORIES: GEO

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