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Precocious Interleukin 21 expression in naïve mice defines a novel stage of T-follicular helper cell development

ABSTRACT: To define early forming IL21-expressing CD4+ T cells at the transcriptional level, we performed RNAseq on FACS-purified splenic CD4+ T cells from naïve 4 wk old IL21-VFP reporter mice based on the following criteria: naïve ICOSlo/- VFP- (N); activated ICOShi VFP- cells not expressing IL21 (ACT); and activated IL21-expressing cells ICOShi VFP+ cells (ACT IL21)

ORGANISM(S): Mus musculus

PROVIDER: GSE67171 | GEO | 2017/03/18

SECONDARY ACCESSION(S): PRJNA279169

REPOSITORIES: GEO

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IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection

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