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Gene expression profiling of transgenic d16HER2- and WT HER2-positive transgenic mammary tumor cell lines

ABSTRACT: d16HER2 is a splice variant of HER2 receptor characterized by a significant tumor aggressiveness. We derived primary tumor cell lines from spontaneous tumors grown in mice transgenic respectively for human d16 (MI6 and MI7 cell lines) and WT HER2 isoforms (WTHER2_1 and WTHER2_2). To analyze the molecular mechanisms underlying the higher tumorigenicity of d16HER2 than that of WTHER2, we conducted gene expression profiling analysis of these cell lines.

ORGANISM(S): Mus musculus

PROVIDER: GSE67300 | GEO | 2016/12/31

SECONDARY ACCESSION(S): PRJNA279460

REPOSITORIES: GEO

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