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Identification of novel functional TBP-binding sites and general factor repertoires

ABSTRACT: We performed a comprehensive ChIP-on-chip analysis for 28 transcription factors on a large set of known and novel TBP binding sites experimentally identified via ChIP-cloning. A large fraction of identified TBP binding sites is located in introns or lacks a gene/mRNA annotation and found to direct transcription. Distinct profiles for general transcription factors and TAF-containing complexes were uncovered for RNAP II promoters located in CpG- and non-CpG islands suggesting distinct transcription initiation pathways. Keywords: TBP, Promoter, ChIP-on-chip, transcription factor profiling

ORGANISM(S): Homo sapiens

PROVIDER: GSE6738 | GEO | 2007/01/17

SECONDARY ACCESSION(S): PRJNA98973

REPOSITORIES: GEO

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