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Genome-wide analysis of chronic inflammation-induced gene expression in primary hepatocytes

ABSTRACT: Analysis of whole genome expression changes in primary hepatocytes in response to chronic stimulation with inflammatory cytokines. We hypothesized that chronic treatment of primary hepatocytes with TNFα would result in a reprogramming of the cell's transcriptome to improve adaptation to the presence of a chronic inflammatory stress. Here we provide expression analysis detailing genes upregulated, downregulated, and unchanged after 2 days of TNFα treatment. We have included gene expression profiling of cells treated with TNFα for 2 hours to help isolate the changes unique to chronic TNFα treatment of primary hepatocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE67422 | GEO | 2016/03/17

SECONDARY ACCESSION(S): PRJNA279860

REPOSITORIES: GEO

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Genome-wide analysis of chronic inflammation-induced gene expression in primary hepatocytes

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