Transcriptomics

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Gonadal Identity in the Absence of pro-Testis Factor SOX9 and pro-Ovary Factor beta-catenin


ABSTRACT: The main goal of our study is to identify the molecular events that determine the gonadal identity in mammals. Although testis and ovary arise from a common embryonic primordium, they represent outcomes of opposing fate determination. This decision to differentiate into a testis or an ovary hinges upon the balance between two antagonizing factors, pro-testis SOX9 and pro-ovary β-catenin. This microarray analysis led to the identification of the genes involved in the fate of XX and XY gonads in absence of SOX9 and beta-catenin

ORGANISM(S): Mus musculus

PROVIDER: GSE67463 | GEO | 2015/05/26

SECONDARY ACCESSION(S): PRJNA279994

REPOSITORIES: GEO

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