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Expression data from MCF-7 breast cancer cells treated with Plumbagin (PL) and its derivative Acetyl Plumbagin (AP)

ABSTRACT: The study aimed at finding the molecular mechanism of action of PL and AP in breast cancer cells. The dataset shows the comparison of gene expression in Plumbagin/Acetyl Plymbagin treated MCF-7 cells when compared with untreated samples.

ORGANISM(S): Homo sapiens

PROVIDER: GSE68026 | GEO | 2015/04/28

SECONDARY ACCESSION(S): PRJNA281582

REPOSITORIES: GEO

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Expression data from MCF-7 breast cancer cells treated with Plumbagin (PL) and its derivative Acetyl Plumbagin (AP)

Project description:The study aimed at finding the molecular mechanism of action of PL and AP in breast cancer cells. The dataset shows the comparison of gene expression in Plumbagin/Acetyl Plymbagin treated MCF-7 cells when compared with untreated samples. 11 samples were analyzed. MCF-7 cells treated with 10 uM PL or AP for 6 hours. Please note that three samples were done in triplicates and one sample MCF-7 treated with 10uM PL was done in duplicates as one of the replicate RNA didn't show up a good RIN number, SAMPLE1 &2 are replicates, SAMPLE 3,4 &5 are triplicates, SAMPLE 6,7 & 8 are triplicates and SAMPLE 9,10 & 11 are triplicates (SAMPLE numbers are indicated in the description field).

2015-04-28 | E-GEOD-68026 | biostudies-arrayexpress

Gene expression signatures for plumbagin (PL) treatment in OSCC cell lines

Project description:Gene expression signatures for plumbagin (PL) treatment in OSCC cell lines

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Gene expression signatures for plumbagin (PL) treatment in OSCC cell lines

Project description:To investigate the effect of PL on gene expression, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to suppress the cell proliferation of OSCC cell lines. SAS and HSC-3 cells were treated with PL (5 μmol/L) for 4 h in vitro.

2021-12-24 | GSE188168 | GEO

Homo sapiens

Project description:Expression data from MCF-7 breast cancer cells treated with Plumbagin (PL) and its derivative Acetyl Plumbagin (AP)

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Expression data from plumbagin-treated B16F10

Project description:Gene expression profiling reveals a potential role of plumbagin on the induction of B16F10 metastasis cells were treated with 0 and 2 µM plumbagin for 24 h ; Microarray gene expression profiling was conducted.

2020-06-27 | GSE153324 | GEO

Mycobacterium tuberulosis H37Rv strains: Control vs. Plumbagin

2010-09-20 | GSE24045 | GEO

Mycobacterium tuberulosis H37Rv strains: Control vs. Plumbagin

Project description:Transcriptional profiling of Mycobacterium tuberculosis H37Rv strains comparing control DMSO treated strains with Plumbagin treated strains. Goal was to determine the effects of Plumbagin against Mycobacterium tuberculosis H37Rv strains. Two-condition experiment,control DMSO vs. Plumbagin. Biological replicates: 2 control replicates, 2 Plumbagin replicates. The file showing raw and normalized data (~4645 rows) extracted from Agilent Feature Extraction Software is linked below. Samples details are described in PDF file linked below (NOTE: The samples 'Plumbagin' and 'chelerythrine' represent the submissions to GEO).

2010-09-20 | E-GEOD-24045 | biostudies-arrayexpress

Changes in miRNA expression profile upon treatment with plumbagin or menadione in SW-620 colorectal cancer cells

Project description:To elucidate the mode of actions of Plumbagin and Menadione, miRNA-profilling was performed after treating cells with vehicle (DMSO), Plumbagin (10uM), and Menadione (10uM) for 24 hours. Threel replicates for control and Menadione and two replicates for Plumbagin were subjected to miRNA-microarray.

2023-03-01 | GSE197300 | GEO

Differential gene expression induced by anti-cancer agent plumbagin is mediated by androgen receptor in prostate cancer cells

Project description:Plumbagin treatment of mice harboring PTEN-P2 tumors in the prostate or on prostate tissue maintained in vivo results in tumor regression when coupled with androgen deprivation therapy. This suggested that dihydrotestosterone (DHT) production in the testes prevents tumor regression due to plumbagin treatment by an unknown mechanism. We performed RNA-seq analysis on cells treated with plumbagin, DHT, or both, and analyzed differential gene expression using RNA-seq. DHT and plumbagin synergize to differentially regulate many genes that are not differentially regulated by either agent alone. For many genes, increases in mRNAs caused by DHT are sharply down-regulated by plumbagin, and some transcripts increase or decrease in response to plumbagin in a DHT-dependent manner. We also observed that plumbagin causes extensive RNA damage independently of DHT. We also include data from a simple time course experiment in which gene expression in response to DHT was studied using RNA-seq.

2017-09-28 | GSE104305 | GEO

Transcriptome profiling of E. coli under different naphthoquinone treatments

Project description:E. coli MG1655 was grown in the presence of either PL (Plumbagin)/JU (Juglone)/ME (Menadione) (50 micro molar) and DMSO (0.75%)as control, and subjected to microarray analysis. The aim of the work was to understand the structure-function relationship between plumbagin and its analogues.

2013-08-14 | E-MEXP-3765 | biostudies-arrayexpress

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