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Cell culture of p63 knock out and wild type bladder epithelial stem cell

ABSTRACT: Although there are several reports describing a stem cell fraction to form urothelium and lineage tracing studies in urinary bladder, it is still unclear about stem cells in mouse bladder epithelium. Here, we have established the cloning system of mouse stem cells from wild type and p63 knockout bladder. We isolated stem/progenitor cells from wild type and p63 knockout epithelium. From wild type bladder, we have cloned keratin 5-positive stem cells, and from p63 knockout epithelium, which loses basal cell fraction, we have cloned morphologically-distinct keratin 8 and claudin 3 positive stem cells, which may be reminiscent of intestinal metaplasia in bladder.

ORGANISM(S): Mus musculus

PROVIDER: GSE68276 | GEO | 2015/10/01

SECONDARY ACCESSION(S): PRJNA282371

REPOSITORIES: GEO

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Cell cloning of Barrett's esophagus stem cell, gastric cardia stem cells and normal esophagus stem cells

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Mus musculus

Project description:Cell culture of p63 knock out and wild type bladder epithelial stem cell

| PRJNA282371 | ENA

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