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Global analysis of genome accessibility in hair follicle stem cells

ABSTRACT: Quiescent stem cells are periodically activated to maintain tissue homeostasis or occasionally called into action upon injury. Molecular mechanisms that constitutively maintain stem cell identity or promote stem cell proliferation and differentiation upon activation have been extensively studied. However, it is unclear how quiescent stem cells maintain identity and reinforce quiescence when they transition from quiescence to activation. Here we show mouse hair follicle stem cell compartment induces a transcription factor, Foxc1, when activated. Importantly, deletion of Foxc1 in the activated but not quiescent stem cells compromises stem cell identity, fails to re-establish quiescence and subsequently drives premature stem cell activation.These findings uncover a dynamic, cell-intrinsic mechanism employed by hair follicle stem cells to reinforce stemness in response to activation.

ORGANISM(S): Mus musculus

PROVIDER: GSE68288 | GEO | 2016/02/05

SECONDARY ACCESSION(S): PRJNA282385

REPOSITORIES: GEO

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Foxc1 reinforces quiescence in hair follicle stem cells

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Project description:Foxc1 reinforces quiescence in hair follicle stem cells

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