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Mesenchymal stromal cells perturb human monocyte in vitro differentiation into dendritic cells

ABSTRACT: Monocytes cultured in media containing GM-CSF and IL4 for 5 days normally differentiate into immature dendritic cells which, upon further stimulation with LPS for an additional 2 days, acquire a mature phenotype. In the present study, we evaluated the effect of human cord-blood mesenchymal stem cells (MSC) on human monocyte differentiation into immature and mature DCs by examining the trancriptional profile of the cells that were obtained after both the differentiation and maturation stages.

ORGANISM(S): Homo sapiens

PROVIDER: GSE68962 | GEO | 2016/05/09

SECONDARY ACCESSION(S): PRJNA284166

REPOSITORIES: GEO

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