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Gene expression profiling on isogenic lines expressing wild-type and mutant forms of SMARCA2 and SMARCA4

ABSTRACT: SMARCA2 and SMARCA4 are two mutually exclusive ATPase subunits of SWI/SNF complex. SMARCA4 deficient lung cancer population selectively depend on SMARCA2 for cancer growth phenotype. Rescue experiments with ectopic expression of wild-type, bromodomain mutant and ATPase dead SMARCA2 and SMARCA4 highlight that ATPase domain is the drug target. In this study, we performed genome-wide microarray and differential gene expression profiling on isogenic lung cancer lines expressing cDNA rescue constructs for wild-type, bromodomain mutant and ATPase dead SMARCA2 and SMARCA4

ORGANISM(S): Homo sapiens

PROVIDER: GSE69088 | GEO | 2015/07/21

SECONDARY ACCESSION(S): PRJNA284505

REPOSITORIES: GEO

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