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Development of gene expression for an INH-responsive transcriptional regulator InbR

ABSTRACT: To further determine the gene expression profile of InbR, encoded by Rv0275c in Mycobacterium tuberculosis, whole genome microarray analysises were applied to inbR-overexpressing strain and wild type Mycobacterium bovis BCG. Comparison of the gene expression pattern of logarithmic growth phase wild-type M. bovis BCG and that of the inbR-overexpression strain revealed a total of 142 genes that were significantly up-regulated (2-fold to 187-fold, p < 0.05) and 200 that were down-regulated (2-fold to 113-fold, p < 0.05). Strikingly, most of the genes in the regulon were predicted to function as molecular chaperones, heat shock proteins, or transcription factors.

ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2

PROVIDER: GSE69379 | GEO | 2015/05/30

SECONDARY ACCESSION(S): PRJNA285333

REPOSITORIES: GEO

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