Transcriptomics

Dataset Information

0

Molecular analysis of normal oviduct, STIC and invasive serous cancer


ABSTRACT: High-grade serous cancer (HGSC) progresses to advanced stages without symptoms and the 5-year survival rate is a dismal 30%. Recent studies of ovaries and fallopian tubes in patients with BRCA mutations revealed that pre-metastatic HGSC is found almost exclusively in the fallopian tube in a lesion termed “serous tubal intraepithelial carcinoma” or STIC. We have performed laser captured microdissection (LCM) of normal oviduct, STIC and invasive serous cancer from each patient. A whole-genome transcriptome analysis comparing between normal oviduct, STIC and invasive serous cancer were performed. We demonstrated a clear molecular progression from normal to STIC, which shared the gene expression patterns with invasive serous cancer, suggesting a new set of genes as basis of novel detection and therapeutic approaches to HGSC at its earliest stage.

ORGANISM(S): Homo sapiens

PROVIDER: GSE69429 | GEO | 2015/09/29

SECONDARY ACCESSION(S): PRJNA285475

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-04-11 | E-GEOD-52011 | biostudies-arrayexpress
2020-07-29 | GSE155311 | GEO
2018-05-15 | GSE114493 | GEO
2017-07-28 | GSE101976 | GEO
2017-08-01 | GSE102073 | GEO
2017-08-01 | GSE102085 | GEO
2014-04-11 | GSE52011 | GEO
| PRJNA285475 | ENA
2024-05-07 | GSE255128 | GEO
2013-12-17 | E-GEOD-49827 | biostudies-arrayexpress