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Next Generation Sequencing of PKD2 mutant mice kidneys

ABSTRACT: This Study sought to understand the differential gene expression profile of Pkd2 mutant mice kidneys in the setting of miR-21 deletion

ORGANISM(S): Mus musculus

PROVIDER: GSE69556 | GEO | 2016/01/05

SECONDARY ACCESSION(S): PRJNA285844

REPOSITORIES: GEO

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Next Generation Sequencing of PKD2 mutant mice kidneys

Project description:This Study sought to understand the differential gene expression profile of Pkd2 mutant mice kidneys in the setting of miR-21 deletion 4 Wild type mice, 3 Pkd2 Knockout mice and 3 Pkd2-miR-21 knockout mice were analyzed

2016-01-05 | E-GEOD-69556 | biostudies-arrayexpress

Next Generation Sequencing of PKD2 mutant mice

Project description:Purpose: Determine the differential gene expression pattern between wildtype, Pkd2-KO and Pkd2-miR-214 KO mice Methods: kidney mRNA profiles of Pkd2-KO and Pkd2-mir-214-KO mice was sequenced with N of 3 in each group Results: 972 differentially expressed transcripts were identified between Pkd2-KO kidneys and Pkd2-miR-214-KO kidneys Conclusion: Deletion of miR-214 promotes interstitial inflammation in mouse models of ADPKD

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Next Generation Sequencing of Pkd1 mutant kidneys

Project description:This study sough to understand the differential gene expression profile of Pkd1 mutant mice kidneys in the setting of miR 17~92 deletion

2017-06-12 | GSE89764 | GEO

Gene expression in pre-cystic mouse kidneys after Pkd2 deletion.

Project description:To identify early transcriptional changes downstream of Pkd2 mutations that promote cyst formation, we used tamoxifen-inducible CAG-Cre to induce Pkd2 deletion at postnatal day 2 and compared to wild-type mice at postnatal day 6 and 10. We then performed gene expression profiling analysis using data obtained from RNA-seq of whole mouse kidneys.

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Next Generation Sequencing of PKD2 mutant mice

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Gene expression in pre-cystic mouse kidneys after Pkd2 deletion.

Project description:Gene expression in pre-cystic mouse kidneys after Pkd2 deletion.

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Small noncoding RNA expression in pre-cystic mouse kidneys after Pkd2 deletion.

Project description:To identify differentially expressed small noncoding RNAs downstream of Pkd2 mutations that may regulate early cyst growth, we used tamoxifen-inducible CAG-Cre to induce Pkd2 deletion at postnatal day 2 and compared to wild-type mice at postnatal day 6 and 10.

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Small noncoding RNA expression in pre-cystic mouse kidneys after Pkd2 deletion.

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Pkd2-dependent transcriptome profile in a newly estabilshed mouse Pkd2 knockout cell line

Project description:Purpose: The goal of this study is to explore early changes of gene expression in the new mouse kidney Pkd2 knockout cell model. To identify compreshensive expressional changes of genes by Pkd2 knockout, transcriptomic changes by Pkd2 knockout induced by doxycycline treatment for 6 days at two different passages were profiled and analyzed. Methods: Total RNAs were isolated from cells treated with or without doxycycline for 6 days. Four replicates of each group were generated. cDNA libraries were prepared and sequenced on Illumina HiSeq4000 platform and then sequence reads were qualified and quantified. Differential expression analysis were performed using edgeR. Results: mRNA profiles of the new mouse kidney Pkd2 knockout cell model treated with doxycycline for 6 days were generated using an optimized RNA-Seq workflow. Transcript level quantification using the STAR quant mode was performed to calculate transcript abundance in each sample. Then differential expression analysis identified the differentially expressed genes at different passages of cell culture. Conclusions: This study revealed early transcriptomic changes dependent on Pkd2 in a new in vitro Pkd2 knockout cell model of the mouse kidney.

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Next Generation Sequencing Analysis of Prenatal Chlorpyrifos Exposure embryonic kidneys

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2019-06-30 | GSE131263 | GEO

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