Transcriptomics

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The role of interleukin-1 beta in the pathophysiology of Schnitzler’s syndrome


ABSTRACT: Schnitzler’s syndrome (SchS) is a disabling autoinflammatory disorder, characterized by chronic urticaria a chronic urticarial rash, an M-protein, arthralgia, and other signs of systemic inflammation. Anti-interleukin-1 (IL-1) beta antibodies are highly effective, but the pathophysiology is still largely unknown. Here we studied the effect of in-vivo IL-1 inhibition on serum markers of inflammation and cellular immune responses.

ORGANISM(S): Homo sapiens

PROVIDER: GSE70019 | GEO | 2015/08/01

SECONDARY ACCESSION(S): PRJNA287499

REPOSITORIES: GEO

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