Transcriptomics

Dataset Information

0

IL-10+ T cells compared to IFNg+/IL-10- T cells induced by IL-10 tolerogenic dendritic cells


ABSTRACT: Ex vivo generated tolerogenic dendritic cells (tDCs) have a strong therapeutic potential to induce antigen-specific iTreg upon infusion in patients. We previously demonstrated that IL-10 tDC-primed T cells are very suppressive and produce IL-10. Here, we show that the majority of the IL-10+ T cells co-express IFNγ, giving rise to the question whether these cells are proinflammatory or regulatory. Whole genome gene expression analysis revealed a strong regulatory gene profile and a suppressed Th1 gene profile for the IL-10/ IFNγ co-expressing CD4+ T cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE70483 | GEO | 2015/07/03

SECONDARY ACCESSION(S): PRJNA288800

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA1061148 | ENA
2013-06-21 | GSE37739 | GEO
2010-12-07 | GSE25846 | GEO
2013-06-21 | E-GEOD-37739 | biostudies-arrayexpress
| PRJNA521498 | ENA
2013-03-04 | GSE35002 | GEO
2012-12-06 | GSE35543 | GEO
2019-09-11 | GSE129260 | GEO
2020-01-06 | E-MTAB-7572 | biostudies-arrayexpress
2010-12-07 | E-GEOD-25846 | biostudies-arrayexpress