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Whole genome expression profiling and analysis on high-charge and energy particle irradiated cells

ABSTRACT: In an attempt to gain insight into the mechanism whereby irradiated cells influence the outcome of DSB repair in their non-irradiated neighbors, we performed whole genome expression profiling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE70532 | GEO | 2015/07/07

SECONDARY ACCESSION(S): PRJNA288960

REPOSITORIES: GEO

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Whole genome expression profiling and analysis on high-charge and energy particle irradiated cells

Project description:In an attempt to gain insight into the mechanism whereby irradiated cells influence the outcome of DSB repair in their non-irradiated neighbors, we performed whole genome expression profiling. Total of 9 samples are analyzed, including 0, 0.3 and 1.0 Gy dose groups, each with 3 biological replicates.

2015-07-07 | E-GEOD-70532 | biostudies-arrayexpress

Irradiated vs sham irradiated keratynocytes

Project description:CEA_SGF:E00006# This set of experiments was performed in order to identify radiation responsive genes. For this, differentiated cultures derived from a single donor were irradiated at either 1 cGy, 2 Gy or sham-irradiated at T0 and total RNA extracts were prepared at 6 time points post-irradiation. Irradiated samples for each dose were hybridized seperately with sham-irradiated samples at the same time point. Each time point for each individual dose was assessed with two independent dye-swap hybridizations. Keywords: time-course

2004-11-01 | GSE1370 | GEO

Genome-wide microarray analysis of immortalized human fibroblasts in response to alpha-particle radiation and the radiation induced bystander effect

Project description:The bystander effect from ionizing radiation consists of cellular responses generated from unirradiated cells to the irradiation of their neighbors. The bystander effect can lead to DNA damage and genomic instability in the affected cells. This non-targeted effect of radiation has received attention due to its potential implications for cancer therapy and radiation protection. Although studied extensively, a complete understanding of its molecular mechanism is the subject of ongoing research. While many studies have targeted specific factors which are suggested to be involved in the bystander effect, few have looked at whole genome gene expression in bystander cells. Furthermore, even fewer studies have looked at the expression in noncancerous human cell lines. In this study we have used a genome-wide microarray approach to investigate transcriptional responses in irradiated and bystander immortalized human fibroblasts following 0.1 Gy ?-particle irradiation. Total RNA was isolated from F11hTERT fibroblasts irradiated with 0.1 Gy ?-particles and bystander fibroblasts receiving medium from control (sham irradiated) and irradiated cells (0.1 Gy). RNA was isolated 4, 8 and 26 h after irradiation.

2011-09-13 | E-GEOD-32091 | biostudies-arrayexpress

RNAseq of irradiated and non-irradiated hemichordate larvae and juveniles

Project description:RNAseq of irradiated and non-irradiated hemichordate larvae and juveniles

| PRJNA804397 | ENA

GLI1 ChIP-Seq in non-irradiated versus irradiated SUM1315 cells

Project description:GLI1 ChIP-Seq in non-irradiated versus irradiated SUM1315 cells

| PRJNA609752 | ENA

bystander effects from irradiated mouse brain

Project description:control: sham irradiated test1: mouse whole brain irradiated 10Gy for once test2:mouse whole brain irradiated 10Gy for 3 times, once a week

2021-01-24 | MSV000086761 | MassIVE

UV irradiated C. elegans

Project description:UV irradiated C. elegans

| PRJNA563824 | ENA

Taurine ameliorates oxidative stress of BMSCs and promotes osteogenesis in irradiated jaws

Project description:Osteoradionecrosis of the jaw (ORNJ) is a complication after head and neck radiotherapy that severely affects patients’ quality of life. Currently, an overall understanding of microenvironmental factors of ORNJ is still lacking. Here, we reveal the activation of taurine metabolism in irradiated mandibular stromal cells with scRNA-Seq and the decrease of taurine in irradiated bone marrow mesenchymal stromal cells (BMSCs) with metabolomics. Compared to the unirradiated BMSCs, the taurine uptake of irradiated BMSCs increases. The taurine concentration in peripheral blood and jaws of irradiated mice are significantly lower than the unirradiated mice. Supplementation of taurine promotes osteogenic differentiation, decreases oxidative stress and DNA damage of irradiated BMSCs. Oral administration of taurine significantly promotes survival rate of irradiated mice and promotes osteogenesis of irradiated jaws. Our study sheds light on the role of taurine during the recovery of radiation-induced jaw injury, suggesting a potential non-invasive therapeutic means to combat ORNJ.

2024-07-08 | MTBLS10284 | MetaboLights

Irradiated mouse: Irradiated mouse vs. non-irradiated mouse

Project description:Adopting boron neutron capture, we separately irradiated Kupffer cells and endothelial cells in mouse liver in vivo and the changes in gene transcriptions were analyzed by an oligonucleotide microarray. Keywords: Gene expression

2007-10-20 | GSE9290 | GEO

Epigenome analysis of irradiated and non-irradiated breast tumor tissue samples and normal controls

Project description:Genome wide DNA methylation profiling of irradiated and non-irradiated breast tumor samples and normal control tissue. The Illumina Infinium 27k Human DNA methylation Beadchip, Genome Build 36 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in breast tumor samples. Samples included 20 non-irradiated tumor samples, 19 irradiated tumor samples and 9 normal controls.

2014-03-26 | GSE50220 | GEO

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