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Regulatory T cells from colonic lamina propria [RNA-Seq]

ABSTRACT: The colonic lamina propria contains a distinct population of Foxp3+ T regulatory cells (Tregs) that modulate responses to commensal microbes. Analysis of gene expression revealed that the transcriptome of colonic Tregs is distinct from splenic and other tissue Tregs. Rorγ and Helios in colonic Tregs mark distinct populations: Rorγ+Helios- or Rorγ-Helios+ Tregs. We uncovered an unanticipated role for Rorγ, a transcription factor generally considered to be antagonistic to Foxp3. Rorγ in colonic Tregs accounts for a small but specific part of the colon-specific Treg signature.

ORGANISM(S): Mus musculus

PROVIDER: GSE71304 | GEO | 2015/07/25

SECONDARY ACCESSION(S): PRJNA290867

REPOSITORIES: GEO

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