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Integrated analysis of methylome and transcriptome of Esophageal Squamous Cell Carcinoma by using Next Generation Sequencing

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71412 | GEO | 2018/02/13

REPOSITORIES: GEO

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Methylome Analysis of Esophageal Squamous Cell Carcinoma by using Next Generation Sequencing

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Integrated analysis of methylome and transcriptome of Esophageal Squamous Cell Carcinoma by using Next Generation Sequencing

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An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.

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Identification of a methylome signature of esophageal squamous cell carcinoma

Project description:Background & Aims: Esophageal squamous cell carcinoma (ESCC) is believed to arise from esophageal mucosa through accumulation of both genetic and epigenetic changes. DNA methylation is a critical epigenetic mechanism involved in key cellular processes and its deregulation has been linked to many human cancers, including ESCC. The aim of this study is to examine the global deregulation of methylation states in ESCC and identify potential early biomarkers. Conclusions: This is the first study to address methylation changes in ESCC in a large panel of genes. Methylome analysis is shown as a sensitive and powerful tool to identify molecular players in ESCC. These data should prove to be the reference for future studies identifying potential biomarkers and molecular targets of ESCC.

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Genome-wide methylation analysis of esophageal squamous cell carcinoma using Infinium HumanMethylation 450 BeadChip

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