Genomics

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Affymetrix 6.0 SNP arrays interrogated to detect allele-specific DNA modification in the brain


ABSTRACT: It has long been hypothesized that knowledge of allele-specific modification (ASM; "modification" is used to denote various types of epigenetic cytosine marks, not only methylation) can supplement and inform GWAS of complex diseases and traits. To explore the relationship between GWAS subthreshold SNPs and ASM, we identified brain ASM-SNPs from Caucasian control individuals (n=76) and Caucasian patients affected by schizophrenia (n=65) or bipolar (n=67) using the Affymetrix SNP 6.0 microarray, one of the most common GWAS platforms which has also been thoroughlyt validated for ASM mapping.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71443 | GEO | 2015/07/29

SECONDARY ACCESSION(S): PRJNA291241

REPOSITORIES: GEO

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