Bisphenol A modulation of DNA repair
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ABSTRACT: To better understand gene expression changes that occur after BPA co-exposure with the oxidizing agent potassium bromate (KBrO3), we have employed whole genome microarray expression profiling to identify genes that are uniquely regulated by exposure to KBrO3, BPA, and co-exposure to both agents. Mouse embryonic fibroblasts deficient in the non-homologous end joining protein Ku70 were exposed to KBrO3, BPA, and both KBrO3 and BPA. Treated samples were isolated 4 and 24 hours after the initiation of DNA damage, along with control untreated samples. Gene expression changes were identified between the treated samples and the controls. From these comparisons, 755 unique gene changes were attributed only to the co-exposure condition at both time points, with only 86 of these genes overlapping between 4 and 24 h. The 24 h time point showed significant up-regulation of DNA repair genes that address oxidatively-induced DNA damage, including Ercc4, Ercc5, Ercc8, and Ogg1.
ORGANISM(S): Mus musculus
PROVIDER: GSE71489 | GEO | 2016/09/26
SECONDARY ACCESSION(S): PRJNA291394
REPOSITORIES: GEO
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