Transcriptomics

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Expression data from CD38high vs CD38low CD11b+Gr1+ splenocytes from tumor-bearing L2-Cre;p120f/f mice.


ABSTRACT: Myeloid derived suppressor cells (MDSCs) are an immunosuppressive population of immature myeloid cells found in advanced stage cancer patients and mouse tumor models. We have identified Cd38 gene as potentially playing an essential role in MDSC biology. To determine the diffences between CD38high and CD38 low MDSCs from tumor-bearing mice, we have conducted this microarray. In this dataset, we include the expression data obtained from sorted splenic CD38high CD11b+Gr1+ cells from tumor-bearing L2-Cre;p120f/f mice, compared to CD38low CD11b+Gr1+ cells from the same mice. Using these data, we have detected differential expression of 498 genes . The Nos2 gene was among the genes most upregulated in CD38high MDSCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE71705 | GEO | 2015/08/31

SECONDARY ACCESSION(S): PRJNA291868

REPOSITORIES: GEO

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