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Modulation of the transcriptional response to TNF-alpha in the human melanoma cell line MZ7 by MITF

ABSTRACT: We analyzed the transcriptional response of the human melanoma cell line MZ7 to TNF-alpha (24 hours) in a dose-dependent manner (TNF-alpha 10U/ml, 100U/ml, 1000U/ml) either transfected with control siRNA (siNT = non-targeting siRNA) or transfected with siRNAs (pool of 4 active and independent siRNAs) against the melanocytic transcription factor and lineage oncogene MITF. (Microphthalmia-associated transcription factor). The experiment was performed as biological duplicate. As MITF is critical for melanoma cell state control, we aimed to explore how MITF expression intersects with inflammation-induced plasticity pathways in melanoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE71798 | GEO | 2015/10/29

SECONDARY ACCESSION(S): PRJNA292099

REPOSITORIES: GEO

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