Genomics

Dataset Information

0

The nuclear receptor REV-ERBa modulates Th17 cell differentiation and function by competing with RORgt


ABSTRACT: T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. The differentiation of Th17 cells is dependent on the retinoic acid receptor-related orphan nuclear receptor RORgt. Here we identify REV-ERBa (encoded by Nr1d1), a member of the nuclear hormone receptor family (NHR), as a transcriptional repressor that antagonizes RORgt function in Th17 cells. REV-ERBa binds to ROR response elements (RORE) in Th17 cells and inhibits the expression of RORgt-dependent genes such as Il17a and Il17f. Furthermore, elevated REV-ERBa expression or treatment with a synthetic REV-ERB agonist significantly delays the onset and impedes the progression of experimental autoimmune encephalomyelitis (EAE), a Th17 cell-mediated autoimmune disease. These results suggest that modulating REV-ERB activity may hold therapeutic potential for treatment of Th17 cell-mediated autoimmune diseases.

ORGANISM(S): Mus musculus

PROVIDER: GSE72271 | GEO | 2019/08/16

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-12-19 | GSE122726 | GEO
2019-07-29 | GSE125696 | GEO
2022-10-26 | GSE211509 | GEO
| PRJNA506082 | ENA
2015-06-16 | GSE67962 | GEO
2015-06-16 | GSE67964 | GEO
2015-06-16 | E-GEOD-67962 | biostudies-arrayexpress
2016-06-29 | E-GEOD-83790 | biostudies-arrayexpress
2015-06-16 | E-GEOD-67964 | biostudies-arrayexpress
2018-02-17 | GSE110765 | GEO