Transcriptomics

Dataset Information

0

Mammary transcriptome of rats treated with low-dose environmental chemicals at critical developmental windows


ABSTRACT: Exposure to common environmental chemicals, including those found in personal care products has been linked to mammary cancer at high doses in animal models. Their effects at low doses at levels comparable to human exposure, especially during critical windows of development remain poorly understood. Using a Sprague-Dawley rat model, we investigated the effects of of three environmental chemicals – diethyl phthalate (DEP), methyl paraben (MPB) and triclosan (TCS) – on the transcriptome of normal developing mammary glands at low doses mimicking human exposure. Rats were exposed during three windows of early development – perinatal (gestation day (GD) 1 - 20 or postnatal day (PND) 1 - 20), prepubertal (PND 21 - 41) and pubertal (PND 42 - 62), as well as chronic exposure from birth to end of lactation (PND 1 - 146). Mammary gland whole-transcriptomes were profiled by Affymetrix rat gene 2.0 st arrays.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE72276 | GEO | 2016/10/19

SECONDARY ACCESSION(S): PRJNA293572

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-04-28 | GSE95554 | GEO
2021-06-11 | MSV000087617 | MassIVE
2024-08-28 | GSE242402 | GEO
2012-09-10 | E-GEOD-40713 | biostudies-arrayexpress
2012-05-21 | E-GEOD-38060 | biostudies-arrayexpress
| PRJNA777904 | ENA
2010-09-25 | E-GEOD-21150 | biostudies-arrayexpress
2013-08-29 | GSE44786 | GEO
2010-11-06 | GSE25043 | GEO
2016-12-06 | E-MTAB-5269 | biostudies-arrayexpress