Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional Response of Mycobacterium tuberculosis H37Rv to Bedaquiline

ABSTRACT: Bacteria commonly adapt to stresses by altering gene expression. To understand the response of M. tuberculosis (MTB) to bedaquiline, we performed transcriptomics over a time-course on MTB bacilli exposed to the drug.

ORGANISM(S): Mycobacterium tuberculosis

PROVIDER: GSE72459 | GEO | 2016/05/05

SECONDARY ACCESSION(S): PRJNA294092

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Mycobacterium tuberculosis transcriptional response to Bedaquiline

Project description:The ability of Mycobacterium tuberculosis (Mtb) to adopt heterogeneous physiological states, underlies it’s success in evading the immune system and tolerating antibiotic killing. Drug tolerant phenotypes are a major reason why the tuberculosis (TB) mortality rate is so high, with over 1.8 million deaths annually. To develop new TB therapeutics that better treat the infection (faster and more completely), a systems-level approach is needed to reveal the complexity of network-based adaptations of Mtb. Here, we report the transcriptional response of Mtb to the drug Bedaquiline. We performed transcriptomic sequencing (RNA-seq) on Mtb bacilli at 4, 24, 72 h following exposure to the drug.

2021-12-15 | GSE166546 | GEO

Mycobacterium tuberculosis H37Rv transcriptional response to antibacterial agents

2015-11-11 | GSE71200 | GEO

Mycobacterium tuberculosis H37Rv transcriptional response to antibacterial agents

Project description:Bacteria commonly adapt to stresses by altering gene expression. To understand the response of M. tuberculosis (MTB) to various antibacterial agents, we performed transcriptomics on MTB bacilli exposed to several test compounds as well as known drugs (capreomycin, cycloserine, ethionamide, isoniazid, kanamycin, moxifloxacin, PA-824, rifampicin, streptomycin). Bacteria were exposed for 16 hrs to various concentrations of each drug (different multiples of the compound's MIC), as noted in the title of each sample. RNA was isolated and applied to arrays provided by TIGR under the NIAID contract N01-AI-15447

2015-11-11 | E-GEOD-71200 | biostudies-arrayexpress

Transcriptional Response of Mycobacterium tuberculosis H37Rv to BTZ043

Project description:To understand the response of M. tuberculosis (MTB) to the drug BTZ043, we performed transcriptomics on MTB bacilli exposed to the drug.

2018-09-07 | GSE119573 | GEO

Transcriptional Response of Mycobacterium tuberculosis H37Rv to Verapamil

Project description:To understand the response of M. tuberculosis (MTB) to the drug verapamil, we performed transcriptomics on MTB bacilli exposed to the drug.

2018-08-02 | GSE118021 | GEO

Transcriptional Response of Mycobacterium tuberculosis H37Rv to Sutezolid

Project description:To understand the response of M. tuberculosis (MTB) to the drug sutezolid, we performed transcriptomics on MTB bacilli exposed to the drug.

2018-08-02 | GSE118018 | GEO

Transcriptional Response of Mycobacterium tuberculosis H37Rv to Delamanid

Project description:To understand the response of M. tuberculosis (MTB) to the drug delamanid, we performed transcriptomics on MTB bacilli exposed to the drug.

2018-08-02 | GSE118008 | GEO

Transcriptional Response of Mycobacterium tuberculosis H37Rv to SQ109

Project description:To understand the response of M. tuberculosis (MTB) to the drug SQ109, we performed transcriptomics on MTB bacilli exposed to the drug.

2018-08-07 | GSE118196 | GEO

Transcriptional Response of Mycobacterium tuberculosis H37Rv to sulfamethoxazole

Project description:To understand the response of M. tuberculosis (MTB) to the drug sulfamethoxazole, we performed transcriptomics on MTB bacilli exposed to the drug.

2018-08-04 | GSE118100 | GEO

Transcriptional Response of Mycobacterium tuberculosis H37Rv to linezolid

Project description:To understand the response of M. tuberculosis (MTB) to the drug linezolid, we performed transcriptomics on MTB bacilli exposed to the drug.

2018-08-04 | GSE118097 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data