The effect of in vitro cultivation on the transcriptome of adult Brugia malayi

ABSTRACT: We examined the global transcriptomic profile of B. malayi females at four different time points (6 biological replicates per time point) over 5 days in culture. Focusing on genes that are differentially expressed at various time points, we observed a general perturbation of the expression profile between dissection from the host and receipt after shipment. The expression of a few genes remained changed at the end of the experiment, after 5 days under controlled conditions; in particular, genes encoding cuticle collagens were prominently represented and strongly overexpressed.

ORGANISM(S): Brugia malayi

PROVIDER: GSE72592 | GEO | 2015/12/02

SECONDARY ACCESSION(S): PRJNA294426

REPOSITORIES: GEO