Genomics

Dataset Information

0

KAP1 Recruitment of the 7SK snRNP to Promoters Enables Transcription Elongation by RNA Polymerase II


ABSTRACT: The transition from transcription initiation into elongation at promoters of primary response genes (PRG) in metazoan cells is controlled by inducible transcription factors, which utilize P-TEFb to phosphorylate RNA Polymerase II (Pol II) in response to stimuli. Prior to stimulation, a fraction of P-TEFb is recruited to promoters in a catalytically inactive state bound to the 7SK small nuclear ribonucleoprotein (snRNP). However, it remains unclear how and why the 7SK snRNP is assembled at promoters. Here we report that the transcriptional regulator KAP1 directly recruits the 7SK snRNP to facilitate localized release of P-TEFb, promoting rapid Pol II elongation and PRG synthesis in response to stimuli. Collectively, we have discovered and characterized a novel complex, which we term the KEC, which dictates rapid and robust PRG induction upon stimuli.

ORGANISM(S): Homo sapiens

PROVIDER: GSE72622 | GEO | 2015/10/09

SECONDARY ACCESSION(S): PRJNA294503

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-06-01 | E-MTAB-6475 | biostudies-arrayexpress
2021-03-30 | GSE147055 | GEO
2013-05-09 | E-GEOD-45517 | biostudies-arrayexpress
2016-02-01 | GSE69139 | GEO
2016-02-01 | GSE69142 | GEO
2016-02-01 | GSE69141 | GEO
2016-02-01 | GSE69140 | GEO
2016-02-01 | GSE72599 | GEO
2013-05-09 | GSE45517 | GEO
2014-11-17 | E-GEOD-56802 | biostudies-arrayexpress