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Profiling of hypothalamus from mice s.c. injected with LL/2(LLC1) lung carcinoma cells vs. PBS

ABSTRACT: The main function of the nervous system is to maintain homeostasis by sensing and reacting to signals that reach a certain threshold 1-5. For example, the brain can sense immune peripheral events through soluble compounds or the vagus nerve and can react through activation of the hypothalamus-pituitary-adrenal axis, resulting in the modulation of an ongoing immune response. Cancer progression is characterized by high mutation rates, with each mutation potentially promoting alarm signals during the 10 to 15 years of cancer development before clinical detection. It is not known, however, whether the brain can recognize the presence of a peripheral tumour, and if this recognition can be molecularly assessed. Using genome-wide expression analysis in a model of lung carcinoma, we show that a tumor growing at the periphery can indeed promote changes in the expression levels of defined sets of genes in the hypothalamus. These changes occur as early as 18 h after tumour cell injection and involve specific signalling pathways. These findings prove that cancer-derived signals are effective in eliciting specific changes in gene expression in discrete brain regions and open a question regarding the potential role of brain genes in cancer outcomes Keywords: gene expression profile of the hypothalamus in response to peripheral tumor cells

ORGANISM(S): Mus musculus

PROVIDER: GSE7295 | GEO | 2007/05/02

SECONDARY ACCESSION(S): PRJNA105023

REPOSITORIES: GEO

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profiling of liver from mice s.c. injected with LL/2(LLC1) lung carcinoma cells vs. PBS

Project description:The main function of the nervous system is to maintain homeostasis by sensing and reacting to signals that reach a certain threshold. For example, the brain can sense immune peripheral events through soluble compounds or the vagus nerve and can react through activation of the hypothalamus-pituitary-adrenal axis, resulting in the modulation of an ongoing immune response. Cancer progression is characterized by high mutation rates, with each mutation potentially promoting alarm signals during the 10 to 15 years of cancer development before clinical detection. It is not known, however, whether the brain can recognize the presence of a peripheral tumour, and if this recognition can be molecularly assessed. Using genome-wide expression analysis in three mouse tumour models, we show that a tumor growing at the periphery can indeed promote changes in the expression levels of defined sets of genes in the brain, but not in the liver. These changes are cancer type - and brain region-specific, occur as early as 18 h after tumour cell injection, involve specific signalling pathways and differ from changes in gene expression induced during arthritis. The brain and specially the hypothalamus can discriminate among different cancer types and between cancer and arthritis by expressing specific sets of genes, highlighting the role of specific brain regions as early sensors of signals emanating from chronic peripheral diseases. These findings prove that cancer-derived signals are effective in eliciting specific changes in gene expression in discrete brain regions and open a question regarding the potential role of brain genes in cancer outcomes Keywords: gene expression profile of the liver in response to peripheral tumor cells

2007-05-02 | GSE7285 | GEO

profiling of midbrain from mice s.c. injected with LL/2(LLC1) lung carcinoma cells vs. PBS

Project description:The main function of the nervous system is to maintain homeostasis by sensing and reacting to signals that reach a certain threshold 1-5. For example, the brain can sense immune peripheral events through soluble compounds or the vagus nerve and can react through activation of the hypothalamus-pituitary-adrenal axis, resulting in the modulation of an ongoing immune response. Cancer progression is characterized by high mutation rates, with each mutation potentially promoting alarm signals during the 10 to 15 years of cancer development before clinical detection. It is not known, however, whether the brain can recognize the presence of a peripheral tumour, and if this recognition can be molecularly assessed. Using genome-wide expression analysis in a model of lung carcinoma, we show that a tumor growing at the periphery can indeed promote changes in the expression levels of defined sets of genes in the midbrain. These changes occur as early as 18 h after tumour cell injection and involve specific signalling pathways. These findings prove that cancer-derived signals are effective in eliciting specific changes in gene expression in discrete brain regions and open a question regarding the potential role of brain genes in cancer outcomes. Keywords: gene expression profile of the midbrain in response to peripheral tumor cells

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profiling of prefrontal cortex from mice s.c. injected with 4T-1 mammary carcinoma cells vs. PBS

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