Transcriptomics

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SK-NEP-1 treated with SKI-5C


ABSTRACT: Wilm’s tumor(WT) is the most common malignant renal tumor in children, representing approximately 6-14% of all childhood cancers and about 95% of all pediatric renal malignancies. SKI-5C is a newly developed Sphk1 inhibitor. This small molecular inhibitor was firstly reported at 2009 by Wang et al. This study investigated the antitumor activity of SKI-5C in SK-NEP-1 cells. SKI-5C inhibited cell proliferation of SK-NEP-1 cells in a dose-dependent manner. Annexin V, Tunel and Hochest 33342 staining analysis showed that SKI-5C-treated cells showed more apoptotic features compared with the control.

ORGANISM(S): Homo sapiens

PROVIDER: GSE72980 | GEO | 2016/12/31

SECONDARY ACCESSION(S): PRJNA295517

REPOSITORIES: GEO

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