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High-throughput single-base resolution mapping of 2’-O-Methylated residues

ABSTRACT: Functional characterization of the transcriptome requires tools for the systematic investigation of RNA post-transcriptional modifications. 2’-O-Methylation of the ribose moiety is one of the most abundant post-transcriptional modifications of the RNA. We describe here a high-throughput method that enables fast and accurate mapping at single-base resolution, and quantitation, of 2’-OMe modified residues. Our approach expands the actual repertoire of methods for transcriptome-wide mapping of RNA post-transcriptional modifications.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE73065 | GEO | 2016/09/13

SECONDARY ACCESSION(S): PRJNA295991

REPOSITORIES: GEO

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