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Circadian regulation of miR-378 mediates circadian controls of cell cycle and metabolism

ABSTRACT: To explore the circadian functions of the miRNAs derived from these circadian primary miRNA transcripts, we focused on miR-378 and examined the transcriptome changes in mouse livers upon miR-378 over-expression at two circadian time points, CT10 and CT22. First, we observed a significant over-representation of the circadian oscillating genes affected by miR-378 over-expression. Cell cycle genes are further enriched in the affected circadian oscillating genes, which implied that miR-378 mediates the circadian control of cell cycle. Our examination of circadian regulatory network involving miR-378 suggests that miR-378 mediates the circadian control of cell cycle and metabolism by forming either coherent or incoherent feed-forward loops with circadian TFs.

ORGANISM(S): Mus musculus

PROVIDER: GSE73308 | GEO | 2016/09/21

SECONDARY ACCESSION(S): PRJNA296571

REPOSITORIES: GEO

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