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A cross species and multi-omics (including metabolomics) analysis in pancreatic neuroendocrine tumours (miRNA)

ABSTRACT: Pancreatic neuroendocrine tumor (PanNET) is relatively infrequent but is nevertheless metastatic. Seeking to extend a new paradigm of personalized medicine, we performed an integrative analysis of transcriptomic (mRNA and microRNA) and mutational profiles and defined three clinically relevant human PanNET subtypes. Importantly, cross-species analysis revealed two of these three subtypes in a well-characterized, genetically engineered mouse model (RIP1-Tag2) of PanNET and its cell lines. Each subtype share similarities to distinct cell types in pancreatic neuroendocrine development, features are reflected in their metabolic profiles. Subtype-specific molecular signatures metabolites are proposed to identify these subtypes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE73367 | GEO | 2015/10/30

SECONDARY ACCESSION(S): PRJNA296884

REPOSITORIES: GEO

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A cross species and multi-omics (including metabolomics) analysis in pancreatic neuroendocrine tumours (tumor stages)

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