Genomics

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Identification of long non-coding RNAs associated with aberrant LKB1 signaling


ABSTRACT: The LKB1 tumor suppressor gene is frequently mutated and inactivated in many cancers, particularly non-small cell lung carcinoma (NSCLC). LncRNAs are a novel class of gene regulators with newly discovered roles in cancer development and progression. LncRNA involvement in altered LKB1 signaling in lung cancer is currently unknown. To investigate whether lncRNAs contribute to loss of LKB1 tumor suppression in lung tumorigenesis and maintenance, we performed genome-wide lncRNA transcriptional profiling to identify lncRNAs associated with aberrant LKB1 signaling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE73414 | GEO | 2016/12/31

SECONDARY ACCESSION(S): PRJNA296909

REPOSITORIES: GEO

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