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In vivo characterization of Linc-p21 reveals functional cis-regulatory DNA elements

ABSTRACT: We have sequenced wildtype and mutant heart, liver, lung, and hindlimb from E14.5 embryos of the mutant lncRNA strain Trp53cor1tm1.1Vlcg (lincp21), and performed a massively parallel reporter assay (MPRA) in mouse myoblast cells (C2C12).

ORGANISM(S): Mus musculus synthetic construct

PROVIDER: GSE73472 | GEO | 2016/08/11

SECONDARY ACCESSION(S): PRJNA297110

REPOSITORIES: GEO

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The Peril DNA locus acts as an in vivo enhancer for distal but not proximal genes

Project description:(1) We have performed a massively parallel reporter assay (MPRA) in C2C12 cells. Additionally, we have (2) sequenced wildtype and mutant ganglionic emminence and olfactory bulb (GE/OB), and kidney from E14.5 mouse pups, as well as mESC from the mutant strain Periltm1.1Vlcg.

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