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MicroRNA expression data from β-hydroxy-β-methylbutyrate (HMB) pre-incubated differentiating equine satellite cells (ESC) exposed to hydrogen peroxide

ABSTRACT: Transcriptional profiling of HMB-treated (24h) differentiating equine satellite cells (3rd day of differentiation) exposed to hydrogen peroxide (1h; last hour of pre-incubation with HMB) compared to control HMB-untreated cells. Goal was to determine the effects of HMB pre-incubation on miRNA expression in equine satellite cells exposed to hydrogen peroxide.

ORGANISM(S): Equus caballus

PROVIDER: GSE73779 | GEO | 2018/04/03

REPOSITORIES: GEO

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Expression data from differentiating equine satellite cells (ESC) culture incubated with HMB and exposed to hydrogen peroxide

Project description:Transcriptional profiling of HMB-treated (24h) differentiating equine satellite cells (3rd day of differentiation) exposed to hydrogen peroxide (1h; last hour of pre-incubation with HMB) compared to control HMB-untreated cells. Goal was to determine the effects of HMB pre-incubation on gene expression in equine satellite cells exposed to hydrogen peroxide.

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Expression data from differentiating primary culture of equine satellite cells (ESC) β-hydroxy-β-methylbutyrate (HMB)

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MicroRNA expression data from gamma-oryzanol (GO) pre-incubated differentiating equine satellite cells exposed to hydrogen peroxide

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Gene expression (GE) data from differentiating equine satellite cells (ESC) culture incubated with phytochemical gamma-oryzanol (GO) and exposed to hydrogen peroxide

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Equus caballus

Project description:Expression data from differentiating equine satellite cells (ESC) culture incubated with HMB and exposed to hydrogen peroxide

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Project description:MicroRNA expression data from β-hydroxy-β-methylbutyrate (HMB) pre-incubated differentiating equine satellite cells (ESC) exposed to hydrogen peroxide

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Chronic Dosed-Feed Toxicity/Carcinogenicity Study of 2-Hydroxy-4-Methoxybenzophenone (HMB, C10260; CAS No. 131-57-7) in Sprague-Dawley rats (G822872B)

Project description:2-Hydroxy-4-methoxybenzophenone (HMB) is an approved Food and Drug Administration (FDA) over-the-counter Category I product considered to be a deterrent to ultraviolet (UV) radiation-induced skin cancer. HMB is used in pharmaceuticals, plastic products, fabric coatings, finishes, and cosmetics. Exposure to HMB occurs through both occupational and consumer routes. HMB is used in skin moisturizing products and sunscreen lotions. In plastics manufacturing, HMB is used in surface coatings and polymers including ABS resins, cellulosic esters, polyesters, polystyrenes, rubber, flexible and rigid vinyl, and vinylidene chloride. HMB readily penetrates the skin and bioaccumulates in lipid-rich tissues. Uptake from the gastrointestinal tract is rapid. This study will characterize the toxicologic and carcinogenic potential of HMB administered in dosed feed to Sprague-Dawley rats given its potential for widespread human exposure as a broad-spectrum sunscreen.

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Produced β-hydroxybutyrate after β-hydroxy-β-methylbutyrate (HMB) administration may contribute HMB function in mice.

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