Targeting innate immunity for antiviral therapy through small molecule agonists of the RLR pathway
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ABSTRACT: To better understand the small molecule agonists that can promote IRF3 activation to induce innate immune gene expression could serve as novel antiviral compounds, we used microarray analysis to assess the transcriptional profiles driven by these compounds and to compare them to known activators of the intracellular innate immune response. We are particularly interested in knowing how the analogs derived by medicinal chemistry (KIN1408 and KIN1409) differ in signaling and gene expression profiles in THP-1 cells as compared to the parent KIN1400 and whether such differences may track with different biological outcomes.
ORGANISM(S): Homo sapiens
PROVIDER: GSE74047 | GEO | 2015/10/16
SECONDARY ACCESSION(S): PRJNA298864
REPOSITORIES: GEO
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