Genomics

Dataset Information

0

BRD4 connects enhancer remodeling to senescence immune surveillance (ChIP-Seq)


ABSTRACT: Cellular senescence is a homeostatic program associated with tumor suppression, wound healing, and certain age related pathologies. Senescent cells display a repressive chromatin configuration thought to stably silence proliferation-promoting genes, while at the same time activate an unusual form of immune surveillance involving a secretory program referred to as the senescence-associated secretory phenotype (SASP). Here we demonstrate that senescence also involves a global remodeling of the enhancer landscape with recruitment of the chromatin reader BRD4 to newly activated super-enhancers adjacent to key SASP genes. Transcriptional profiling and functional studies indicate that BRD4 is required for the SASP and downstream paracrine signaling. Consequently, BRD4 inhibition disrupts immune cell-mediated targeting and elimination of premalignant senescent cells in vitro and in vivo. Our results identify a critical role for BRD4-bound super-enhancers in senescence immune surveillance and in the proper execution of a tumor-suppressive program.

ORGANISM(S): Homo sapiens

PROVIDER: GSE74238 | GEO | 2016/04/15

SECONDARY ACCESSION(S): PRJNA299593

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-04-15 | GSE74324 | GEO
2023-01-28 | GSE223874 | GEO
2023-01-17 | GSE203140 | GEO
2016-07-04 | E-GEOD-62701 | biostudies-arrayexpress
2021-02-20 | ST001708 | MetabolomicsWorkbench
| PRJNA299780 | ENA
2024-03-15 | MSV000094326 | GNPS
2024-06-26 | GSE207825 | GEO
2024-06-26 | GSE207818 | GEO
2024-06-26 | GSE207816 | GEO