Transcriptomics

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Systematic drug perturbations of cancer cells reveal diverse exit paths from the proliferative state


ABSTRACT: Analysis of the time courses of gene expression profiles of breast cancer cell line MCF7 treated by 16 differentiation-inducing drugs at day 1, day 3 and day 5. The drugs are the screening results from the the JHCCL library (1,500 drugs). The hypothesis tested in the present study was that cancer cells exit the proliferative state via multiple paths. Results showed that cell state transition trajectories firstly diverged and later converged to a quiescient differentiated state

ORGANISM(S): Homo sapiens

PROVIDER: GSE74281 | GEO | 2015/10/23

SECONDARY ACCESSION(S): PRJNA299623

REPOSITORIES: GEO

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