Gene expression profiles of prostate cancer cell line with or without HDAC inihbitors

ABSTRACT: Histone deacetylase (HDAC) inibitors suppress cell proliferation of prostate cancer, but the detailed mechanisms are unknown. Moreover, HDAC includes 18 family members, namely HDAC1-11 and SIRT1-7, and differences of effects on prostate cancer proliferation among these enzymes are also unknown. Thus, we clarified differences of gene expression between prostate cancer cell line (LNCaP) treated with pan-HDAC inhibitors (TSA and OBP-801) or selective HDAC inhibitor (NCC-149, HDAC8-specific inhibitor)using cDNA microarray.

ORGANISM(S): Homo sapiens

PROVIDER: GSE74418 | GEO | 2015/11/04

SECONDARY ACCESSION(S): PRJNA300937

REPOSITORIES: GEO